منابع مشابه
Concentrated insulins: the new basal insulins
INTRODUCTION Insulin therapy plays a critical role in the treatment of type 1 and type 2 diabetes mellitus. However, there is still a need to find basal insulins with 24-hour coverage and reduced risk of hypoglycemia. Additionally, with increasing obesity and insulin resistance, the ability to provide clinically necessary high doses of insulin at low volume is also needed. AREAS COVERED This ...
متن کاملAnimal Insulins - Current Status
There is no significant difference in the metabolic control with animal or human insulin. At present there is no clinical data comparing the diabetes related mortality and complications, with animal or human insulin. The earlier animal insulins were more immunogenic as compared to human insulin, but the present day highly purified monocomponent insulins are less antigenic and the difference in ...
متن کاملHow to Accurately Establish Pharmacokinetics/Pharmacodynamics of Long-Acting Insulins in Humans: Relevance to Biosimilar Insulins.
In this issue of Diabetes Care, Linnebjerg et al. (1) compare the pharmacokinetics (PK) and pharmacodynamics (PD) of a Lilly synthetized insulin glargine (LY IGlar) with the insulin glargine Lantus (IGlar) based on a series of clamp studies in healthy volunteers and conclude for PK/PD that there is similarity of the LY IGlar vs. IGlar. The strengths of the study should be discussed along with i...
متن کاملBiosimilar insulins: a European perspective
Biosimilar insulins are likely to enter clinical practice in Europe in the near future. It is important that clinicians are familiar with and understand the concept of biosimilarity and how a biosimilar drug may differ from its reference product. The present article provides an overview of biosimilars, the European regulatory requirements for biosimilars and safety issues. It also summarizes th...
متن کاملCardiovascular effects of basal insulins
Basal insulin is an important component of treatment for both type 1 and type 2 diabetes. One of the principal aims of treatment in patients with diabetes is the prevention of diabetic complications, including cardiovascular disease. There is some evidence, although controversial, that attainment of good glycemic control reduces long-term cardiovascular risk in both type 1 and type 2 diabetes. ...
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ژورنال
عنوان ژورنال: Australian Prescriber
سال: 2002
ISSN: 0312-8008,1839-3942
DOI: 10.18773/austprescr.2002.032